Immunomodulation of the Avian Innate Immune Response to Prevent Bacterial Infection in Poultry

Objective

<ol> <li>Evaluate cloned cytokines identified in Salmonella enteritidis-immune lymphokine (SILK) in Salmonella poultry model;
<li>Isolate and functionally analyze the cellular components of the innate host defenses; and
<li>Identify and produce molecular probes for toll receptors on cells of the innate immune system</ol>

More information

We are evaluating the effect of recombinant avian cytokines (p33, IFN-gamma, IL-8, IL-18, IL-15) on Salmonella enteritidis organ invasion in day-of-hatch chickens. We are currently developing DNA expression vectors constructed from PCR-generated cDNA of human Toll receptors. These vectors will be used to determine the presence of these receptors on cells of the innate host defenses.

Investigators

Kogut, Michael

Institution

USDA - Agricultural Research Service

Start date

2001

End date

2006

Funding Source

Agricultural Research Service

Project number

6202-32000-014-00D

Accession number

403940