The overall goal of the current project is to build SUAREC competency in plant based nutraceuticals that promote human health and wellness. The proposed research activities will include: a) modulating health relevant bioactive compounds in grapes; b) extraction, identification, and testing of compounds from grapes; and c) analyzing their nutraceutical property using existing in vitro model systems.The specific objectives of the project are:1. To enhance the nutraceutical-phytochemicals content of muscadine berry through stimulants/elicitors. 2. To determine the gene expression associated with flavonoid and stilbenoid synthesis in berries.3. To determine the effect of berry extracts on CSE-regulated inflammatory and protein homeostatic mechanisms in human lung epithelial cells.4. To develop leadership and technical skills of minority students in agriculture/ molecular biology research.