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Interagency Agreement on Developing and Evaluating Risk Assessment Models for Key Waterborne and Foodborne Pathogens and Chemicals


To develop and to evaluate risk assessment models and chemical risk assessments for food and water. <P>This is a proposal for a new interagency agreement between NCTR and EPA's National Center for Environmental Assessment.

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FY 2000 Accomplishments:<ol><li>Set up an IAG with EPA's National Center for Environmental Assessment toconduct collaborative research on microbial risk assessment and on riskassessment for chemical mixtures. <li>FY 2000 funding from EPA. <li>Drafted a protocol to conduct animal experiments on model development fortransmission kinetics of infection by Cryptosporidium parvum, a foodbornepathogen of critical concern to FDA. <li>Began development of a strategy for examining various strategies for assessingthe cumulative risk of mixtures of chemicals, in particular those having similarmodes of action.
FY 2001 Plans:
<ol><li>Finalize initial animal protocol in conjunction with NCTR, CFSAN, and EPA.
<li>Conduct animal experiments on C. parvum.
<li>Carry out cumulative risk assessment for selected organophosphates on EPA Candidate Contaminant List with EPA scientists.
<li>Develop a protocol for a refined strategy for cumulative risk assessment ofmixtures.
<li>Report results to EPA and FDA.
<li>Prepare manuscripts for publication.</ol>

Kodell, Ralph
DHHS/FDA - National Center for Toxicological Research
Project number