To develop and to evaluate risk assessment models and chemical risk assessments for food and water. <P>This is a proposal for a new interagency agreement between NCTR and EPA's National Center for Environmental Assessment.
FY 2000 Accomplishments:<ol><li>Set up an IAG with EPA's National Center for Environmental Assessment toconduct collaborative research on microbial risk assessment and on riskassessment for chemical mixtures. <li>FY 2000 funding from EPA. <li>Drafted a protocol to conduct animal experiments on model development fortransmission kinetics of infection by Cryptosporidium parvum, a foodbornepathogen of critical concern to FDA. <li>Began development of a strategy for examining various strategies for assessingthe cumulative risk of mixtures of chemicals, in particular those having similarmodes of action.
FY 2001 Plans:
<ol><li>Finalize initial animal protocol in conjunction with NCTR, CFSAN, and EPA.
<li>Conduct animal experiments on C. parvum.
<li>Carry out cumulative risk assessment for selected organophosphates on EPA Candidate Contaminant List with EPA scientists.
<li>Develop a protocol for a refined strategy for cumulative risk assessment ofmixtures.
<li>Report results to EPA and FDA.
<li>Prepare manuscripts for publication.</ol>