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Molecular Mechanisms of the Inflammatory Response Induced by Shigella Flexneri


Despite the understanding gained by our long-standing interest in studying Shigella, shigellosis continues to pose worldwide medical concerns and remains a cause of food-borne diseases even in developed countries. The identification of host cellular targets of Shigella virulence proteins will aid clinical therapeutic drug designs and treatment of multidrug-resistant bacteria. <P> Results from this study will not only broaden our understanding of Shigella pathogenesis but will also provide vital insights into basic host cell biology.

McCormick, Beth
University of Massachusetts Medical School - Worcester
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