An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

OSIB: CO-EVOLUTIONARY DYNAMICS OF PATHOGEN VIRULENCE AND HOST RESISTANCE: LESSONS FROM FUSARIUM OXYSPORUM-INFESTED COTTON FIELDS

Objective

With the growing population and limits on arable lands, agriculture struggles to increase the yield and quality of food, fiber, and biofuel crops. Reducing crop disease losses is a key to addressing this challenge. Effective disease management relies on a mechanistic understanding of pathogen population dynamics, virulence basis, and host resistance determinants in the field. The project is rooted in a recent disease outbreak of cotton Fusarium wilt caused by Fusarium oxysporum f. sp. vasinfectum (Fov) in some southern U.S. states. With multiple consecutive years of pathogen characterization and germplasm screens from a naturally infected cotton field in El Paso County, Texas, the team has obtained comprehensive field and laboratory data for raising the compelling hypothesis about the evolution and pathogenicity of F. oxysporum, building the invaluable resources for resistance gene identification, and providing the molecular insights of F. oxysporum-host interactions. In addition, the team has developed multiple platforms for transient and stable loss- and gain-of-function assays in cotton. With these advances, the team aims to reveal the complex mechanisms of fungal pathogenicity and host resistance by determining 1) the genetic diversity, evolution, and pathogenicity of Fov and comparative genomics of F. oxysporum species complex (FOSC), and 2) cotton resistance mechanisms to Fusarium wilt by targeted sequencing and association genomics. The research represents a systems approach to deciphering co-evolutionary dynamics of pathogen virulence and host resistance in the complex genome of a devastating pathogen and an essential crop.

Investigators
He, P.; Wheeler, TE, .; Dever, JA, K..; Shan, LI, .
Institution
UNIVERSITY OF MICHIGAN
Start date
2024
End date
2027
Project number
MICW-2023-11868
Accession number
1031875
Categories