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PBPK Models for Bisphenol A


<li>Create physiologically based pharmacokinetic (PBPK) models for BPA in mouse, rat, and rhesus nonhuman primate of adult, neonatal, pregnant (mother and fetus), and lactating (mother and neonate) laboratory animals. These models will be used to calculate internal measures of dose for both active and inactive forms of BPA.</li>
<li>Create human PBPK models for BPA (adult, child, pregnant mother and fetus, and lactating mom and infant) using data from the nonhuman primate, mouse, and rat, and limited human information from literature. The human suite of models will be used to extrapolate the internal toxic doses of BPA in laboratory animals to humans. The PBPK models will also be used to extrapolate dosimetry from regions of observation to low levels of exposure to BPA for which no experimental data exist.</li>
<li>Interpret biomonitoring data for BPA in urine and blood.</li></ol></p>

More information

Responsible Division: Biochemical Toxicology

Fisher, Jeffrey
DHHS/FDA - National Center for Toxicological Research
Project number