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Pro-Inflammatory Response to Campylobacter and Heat-Stable Campylobacter Products


Human colonic epithelial cells respond to Campylobacter jejuni by activation of the transcription factor NF-kB to induce innate immunity and switch on pro-inflammatory cytokines. C. jejuni cell components stable to heat treatment constitute a potent activator of NF-kB leading to the efficient induction of cytokines/chemokines including interleukin-8. <P>
We propose to characterise the bioactive components of Campylobacters and examine human gut epithelial cell responses to these products.

University of Nottingham
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