To determine the risk associated with exposure to malachite green or leucomalachitegreen.
FY 2000 Accomplishments: 1) Bioassay and mechanistic studies are ongoing. 2) A paper describing mechanistic studies has been accepted. Another paper was published.
FY 2001 Plans: 1) Complete In-life phase of bioassay with malachite green/leucomalachite green in mice. 2) Complete pathology on bioassay (NTP report will be completed in 2002). 3) Mechanistic studies will continue with emphasis on the role of demethylated metabolites in the metabolic activation of malachite green/leucomalachite green.