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National Agricultural Library
U.S. Department of Agriculture
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  4. Two-Year Bioassay in Mice Administered Malachite Green or Leucomalachite Green in the Diet

Two-Year Bioassay in Mice Administered Malachite Green or Leucomalachite Green in the Diet

Objective

To determine the risk associated with exposure to malachite green or leucomalachitegreen.

More information

FY 2000 Accomplishments: 1) Bioassay and mechanistic studies are ongoing. 2) A paper describing mechanistic studies has been accepted. Another paper was published.

FY 2001 Plans: 1) Complete In-life phase of bioassay with malachite green/leucomalachite green in mice. 2) Complete pathology on bioassay (NTP report will be completed in 2002). 3) Mechanistic studies will continue with emphasis on the role of demethylated metabolites in the metabolic activation of malachite green/leucomalachite green.

Investigators
Culp, Sandra
Institution
DHHS/FDA - National Center for Toxicological Research
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0212701