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National Agricultural Library
U.S. Department of Agriculture
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  4. Two-Year Chronic Toxicology Study of Bisphenol A (BPA) Administered by Gavage to Sprague-Dawley Rats from Gestational Day-6 until Birth and Directly to Pups from Post-Natal Day (PND)-1, Continuous and Stop Dose (PND-21) Exposures

Two-Year Chronic Toxicology Study of Bisphenol A (BPA) Administered by Gavage to Sprague-Dawley Rats from Gestational Day-6 until Birth and Directly to Pups from Post-Natal Day (PND)-1, Continuous and Stop Dose (PND-21) Exposures

Objective

<p>Characterize the long-term toxicity of orally administered BPA, including developmental exposure, in the NCTR Sprague-Dawley rat over a broad dose range. In addition, animals generated in this study will be assigned to separate protocols for assessment of a range of molecular, morphological, and functional endpoints to determine if these endpoints are predictive of longterm toxic effects or reveal potential effects undetected by standard toxicological evaluations.</p>

More information

Responsible Division: Biochemical Toxicology

Investigators
Delclos, Kenneth
Institution
DHHS/FDA - National Center for Toxicological Research
DHHS- National Toxicology Program
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0219001
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