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In Vivo and in Vitro Reporters for Androgen and Ah Receptor Responses to Food Components


This research project aims to develop screening methods to detect potentially harmful chemicals in food.

<p>This project will develop methods to detect chemicals capable of activating the androgen receptor or the Ah receptor in cultured cells and in an experimental model system.

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Foods can contain potentially harmful chemicals, either as natural constituents, as contaminants, or as by-products of food processing and cooking.

<p>In order to identify harmful chemicals present in foods and to assess the risks they may pose to human health, sensitive tests to detect and measure them must be developed.

<p>Some harmful chemicals found in foods exert their effects by interacting with cell receptors which affect the expression of specific genes.

<p>This project aims to develop tests to examine whether food components can bind to and activate two types of receptor: <ul>

<li>the androgen receptor, which plays a role in normal sexual development and function in males
<li>the arylhydrocarbon (Ah) receptor, which recognises a range of toxic compounds such as dioxin

The final report, "<a href="; target="_new">In Vivo and in Vitro Reporters for Androgen and Ah Receptor Responses to Food Components</a>" is available at Foodbase, an open access repository of the <acronym title="Food Standards Agency">FSA</acronym>.

<p>Find more about this project and other FSA food safety-related projects at the <a href="; target="_blank">Food Standards Agency Research webpage</a>.

University of Dundee
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