News
The Johns Hopkins Center for Alternatives to Animal Testing (CAAT) is now accepting proposals for the 2019 Science-Based Refinement Awards.
A new priority of the CAAT Refinement Program is to help fund systematic reviews of frequently used and/or severe animal models to either refine them – if proven valid – or, when they are not representative for the intended purpose (e.g., to model a specific human malady), to demonstrate their weaknesses in an unbiased manner.
CAAT continues to fund non-invasive animal research projects to enhance the housing, handling, and/or experimental procedures for laboratory animals or that can reduce animal use.
Hence, the small grants are intended for those who work hands-on with animals, such as animal welfare scientists, veterinarians, and animal care technicians, as well as for researchers who conduct systematic reviews and meta-analyses of animal studies.
For information and application instructions, see CAAT Refinement Awards 
The Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM) has published a report summarizing activities of member agencies during 2016 and 2017. The 2016-2017 ICCVAM Biennial Report is available at https://ntp.niehs.nih.gov/iccvamreport/2017/index.html.
The report highlights member agency activities supporting toxicology innovation, as well as regulatory agency initiatives to promote the 3Rs (replace, reduce, or refine animal use) and to provide information about the use of in vitro methods.
Key ICCVAM, ICCVAM agency and NICEATM accomplishments summarized in the report include:
- Publication of A Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United States.
- Guidance documents published by the U.S. Environmental Protection Agency (EPA) describing approaches to reduce animal use in testing required for pesticide registration.
- Notices published by the U.S. Department of Agriculture describing approaches to reduce animal use for vaccine testing.
- A Predictive Toxicology Roadmap published by the U.S. Food and Drug Administration (FDA).
- A non-animal defined approach developed by NICEATM and EPA that identifies substances that may interact with the androgen receptor.
- A non-animal defined approach developed by NICEATM and ICCVAM to predict skin sensitization risk.
- A proposed method developed in collaboration with international partners to evaluate non-animal approaches to identify skin sensitizers.
- Launch of the NICEATM Integrated Chemical Environment (ICE), an online resource that provides high-quality curated data and computational workflows for chemical safety assessment.