Antimicrobial Properties of Zinc Oxide (ZnO) and Titanium Oxide (TiO2) Nanoparticles (NPs) Against Multidrug-Resistant Staphylococcus and Enterococcus spp. and Their Cytotoxic and Genotoxic Potential in Bacteria and Normal Human Epidermal Keratinocytes (N

Objective

<p>
<ol>
<li>Study the mechanism of antimicrobial properties of TiO2 and ZnO Nanoparticles (NPs) in multidrug-resistant Staphylococcal and Enterococcal spp.</li>
<li>Study synergy between NPs and antibiotics.</li>
<li>Evaluate the cytotoxic and genotoxic potential of NPs in bacterial, and normal human epidermal keratinocytes (NHEK) and primary intestinal-cell lines.</li>
<li>Study the transcriptomic gene expression in NHEK and intestinal-cell lines.</li></ol></p>

More information

Responsible Division: Microbiology

Investigators

Khan, Saeed

Institution

DHHS/FDA - National Center for Toxicological Research

Funding Source

Nat'l. Center For Toxicological Research

Project number

E0751501