(1) Enhance surveillance and monitoring of antibiotic resistance and develop improved diagnostic tests. (2) Determine the ecology and mechanisms involved in resistance and transmission of resistance. (3) Develop and evaluate interventions (including alternatives to antibiotics) that reduce antimicrobial resistance in food production systems. (4) Quantify animal health, public health, social, economic, and environmental impacts of antimicrobial interventions in food production systems. (5) Create and deliver programs on antibiotic stewardship in food production systems through education and outreach.