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Development of Methods for Analysis and Confirmation of b-Agonists


<li> To develop determinative and confirmatory procedures using Liquid Chromato-graphy-Atmospheric Pressure Chemical Ionization Mass Spectrometry (LC-APCI/MS) for multiresidue screening b-agonists in livestock tissues. </li>
<li> To develop synthetic procedures to produce authentic b-agonists standards for use in regulatory screening. These methods will provide the flexibility to adapt to the potential for 'designer drug' modifications by clandestine laboratories. </li>
<li> To explore the use of packed column supercritical fluid chromatography (SFC)coupled with APCI/MS as a more efficient technique for chromatographic separation the screening of large numbers of b-agonists in livestock tissues.</li> </ol>

More information

FY 2000 Accomplishments: Residue study for ractopamine undertaken in collaboration with the U.S. Department of Agriculture (USDA).</p>
FY 2001 Plans:Complete ractopamine residue analysis from USDA feeding trial.</P>

Doerge, Daniel
DHHS/FDA - National Center for Toxicological Research
Project number