An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

National Agricultural Library
U.S. Department of Agriculture
  1. Home
  2. Research Tools
  3. Food Safety Research Projects Database
  4. Development of Methods for Analysis and Confirmation of b-Agonists

Development of Methods for Analysis and Confirmation of b-Agonists

Objective

<ol>
<li> To develop determinative and confirmatory procedures using Liquid Chromato-graphy-Atmospheric Pressure Chemical Ionization Mass Spectrometry (LC-APCI/MS) for multiresidue screening b-agonists in livestock tissues. </li>
<li> To develop synthetic procedures to produce authentic b-agonists standards for use in regulatory screening. These methods will provide the flexibility to adapt to the potential for 'designer drug' modifications by clandestine laboratories. </li>
<li> To explore the use of packed column supercritical fluid chromatography (SFC)coupled with APCI/MS as a more efficient technique for chromatographic separation the screening of large numbers of b-agonists in livestock tissues.</li> </ol>

More information

<p>
FY 2000 Accomplishments: Residue study for ractopamine undertaken in collaboration with the U.S. Department of Agriculture (USDA).</p>
<p>
FY 2001 Plans:Complete ractopamine residue analysis from USDA feeding trial.</P>

Investigators
Doerge, Daniel
Institution
DHHS/FDA - National Center for Toxicological Research
Funding Source
Nat'l. Center For Toxicological Research
Project number
E069450