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National Agricultural Library
U.S. Department of Agriculture
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  4. Development of Methods for Evaluating DNA Damage Using Single-Cell Gel Electrophoresis (Comet Assay) in Rodents

Development of Methods for Evaluating DNA Damage Using Single-Cell Gel Electrophoresis (Comet Assay) in Rodents

Objective

<p>
Evaluate and establish methods and conditions that enhance the sensitivity and reproducibility of the in vivo alkaline-comet assay for use in preclinical-hazard identification and genotoxicity testing of food ingredients and chemicals for regulatory purposes.</p>

More information

Responsible Division: Genetic and Modernizing Toxicology

Investigators
Manjanatha, Mugimane
Institution
DHHS/FDA - National Center for Toxicological Research
DHHS/FDA - Center for Food Safety & Applied Nutrition
Funding Source
Nat'l. Center For Toxicological Research
Project number
E0729001
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