Skip to main content

Development of Methods for Evaluating DNA Damage Using Single-Cell Gel Electrophoresis (Comet Assay) in Rodents

Objective

<p>
Evaluate and establish methods and conditions that enhance the sensitivity and reproducibility of the in vivo alkaline-comet assay for use in preclinical-hazard identification and genotoxicity testing of food ingredients and chemicals for regulatory purposes.</p>

More information

Responsible Division: Genetic and Modernizing Toxicology

Investigators
Manjanatha, Mugimane
Institution
DHHS/FDA - National Center for Toxicological Research
DHHS/FDA - Center for Food Safety & Applied Nutrition
Project number
E0729001