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Evaluation of the Applicability of In vivo Micronucleus Assays for Assessing Genotoxicity of Engineered Nanomaterials



<li>Assess the genotoxicity of four types of nanoscale materials, carbon nanotubes, nanoscale titanium dioxide, nanoscale gold, and nanoscale silver in three standard tests suggested by FDA; Salmonella Ames test, mouse lymphoma assay, and in vivo mouse micronucleus assay.</li>
<li>Evaluate the possible mechanisms of nanomaterial-induced genotoxicity using a transgenic mutation system comet assay, and genomic analysis.</li>


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Responsible Division: Genetic and Molecular Toxicology

Chen, Tao
DHHS/FDA - National Center for Toxicological Research
DHHS - Centers for Disease Control and Prevention (CDC)
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