Food Animal Residue Avoidance Databank (FARAD) VMCVM Component

VMCVM Regional Access Center Work Plan: During the 2018-2019 project year.The regional center at VMCVM will continue to support the essential tasks of the national FARAD program outlined below, provide pharmacokinetic services to all FARAD sites, and continue developing pharmacokinetic model tools that allow FARAD responders to fully utilize published studies to avoid meat and milk violative residues in food animals. The primary focus areas of the VMCVM FARAD component for 2018 - 2019 are as follows: (1) strengthen the response team via the hiring of a veterinary pharmacology resident and graduate student (Dr. Mercer) and, in collaboration with NCSU and UC Davis, provide drug and chemical residue management expertise to veterinarians by answering telephone and internet inquiries; (2) collaborate with NCSU, KSU, UC Davis, and University of Florida, to validate (via in vivo studies) many of our computational estimates of a safe withdrawal time.Respond to drug and chemical residue cases The VMCVM FARAD Regional Access Center will continue in collaboration with NCSU and UC-Davis FARAD Regional Access Center to answer residue avoidance inquiries. This service will require the veterinary clinical pharmacology expertise of Dr. Jennifer Davis and a Veterinary Pharmacology Resident/PhD student, Dr. Melissa Mercer (DVM, MS). Dr. Mercer will be responsible for daily management of cases at VMCVM. This represents a new response center and will facilitate the accuracy and timeliness of FARAD's response to as many as 70 cases a week. VMCVM will also collaborate and contribute to writing timely FARAD Digests that focus on the management of the more common drug residue scenarios facing food animal veterinarians. We will collaborate in outreach programs to producer groups and veterinary specialty groups such as AVMA, AABP, AAVPT. Dr. Davis is the current Secretary of AAVPT and is uniquely positioned to ensure continued collaboration between AAVPT and FARAD. The VMCVM also has a long-standing relationship with the FDA Center for Veterinary Medicine through providing externship opportunities for students and potentially FARAD graduate students/residents. Our proximity to the FDA facilities is a great advantage in this area.Pharmacokinetic TrialsVMCVM will collaborate with NCSU and UC-Davis to obtain in vivo data to validate FARAD approved withdrawal intervalcommendations. his will be accomplished by participation in in vivo pharmacokinetic studies in food producing animals to determine detection times of drug in products such as eggs, milk or tissues. VMCVM has a fully equipped Pharmacology/Toxicology laboratory that will complement facilities currently in use at NCSU and UC-Davis. Animals and animal facilities are also available through the VMCVM.