Further Development and Refinement of the FDA Endocrine Disruptor (ED) Knowledge Base (EDKB) for Assessing Endocrine Disrupting Potential of Drugs and Food Additives (E0741501)

Objective

<p>
<ol>
<li>Improve EDKB by including the ED data that will be generated by NTP and NCTR as well as estrogen receptor and androgen receptor data generated at EPA, and data that have been published in the past eight years.</li>
<li>Conduct meta-analyses of the large datasets accumulated in the EDKB to gain a better understanding of chemical
structure requirement and mechanisms related to EDs. </li>
<li>Investigate various chemoinformatics/bioinformatics approaches to develop effective predictive models for assessing the potential of drugs and food additives.</li></ol></p>

More information

Responsible Division: Bioinformatics and Biostatistics

Investigators

Hong, Huixiao

Institution

DHHS/FDA - National Center for Toxicological Research

Funding Source

Nat'l. Center For Toxicological Research

Project number

E0741501