Immune Assay to Evaluate Cross-Protection Following Influenza Virus Vaccination

<p>Using samples from live-animals, evaluate cross-reactive antibody and T cell response elicited following vaccination with different vaccines to identify a surrogate of protection, both at local and systemic levels. This work is extended to include evaluation of immune responses following vaccination in the presence of maternal immunity specific to the vaccine antigen. Work also includes evaluation of lactogenic immunity – specifically, evaluation of immune responses (antibody and/or T cell responses) to vaccine antigen in sows and the transfer of such immunity to piglets through colostrum and/or milk.</p>