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Method Performance Verification for the Analysis of Minor Clam Species for Paralytic Shellfish Poisoning Toxins


<p>The AOAC HPLC method 2005.06, which involves the acetic acid extraction of shellfish prior to clean up, derivatisation and HPLC analyses, was subjected to a method performance verification exercise at Cefas for four further clam species of UK commercial significance: (surf, manila, carpet shell and otter clams). Checks followed guidance from the AOAC including an assessment of method selectivity, sensitivity, recovery, precision and uncertainty of measurement. Performance checks were conducted on the major PSP toxins commercially available as standards and more commonly found in UK samples.</p>

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<p>Background: The mouse bioassay (MBA) is the official reference method for determination of PSP toxins (PSTs) in bivalve shellfish. However, in recent years the AOAC HPLC method 2005.06 has become an approved alternative Official Method by the European Commission and has already been validated and implemented into the UK official control monitoring programme for mussels, cockles, razors and hard clams. </p>

Centre for Environment, Fisheries and Aquaculture Sciences (CEFAS)
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