To develop, if possible and practical, a variety of new technologies for improving high performance liquid chromatography (HPLC) detection. By eliminating hazards associated with radioactivity, it can make possible metabolic drug studies involving human subjects. Several Cooperative Research and Development Agreements (CRADAs) will be negotiated during the work to facilitate development of commercial versions of the devices which show the most promise.
Redesign of Model B interface performance and characterization completed and results presented jointly by NCTR and the CRADA partner at PittCon 2000. A usable Chemical Reaction Interface Mass Spectrometry (CRIMS) microwave cavity and advanced versions of diffusion cells are available for testing and re-design.
Model C interface will be developed/evaluated under experiment X10010.
The ultimate objective of this work is to develop, if possible and practical, a variety of new technologies for improving high performance liquid chromatography (HPLC) detection. By eliminating hazards associated with radioactivity, it can make possible metabolic drug studies involving human subjects. Several CRADAs will be negotiated during the work to facilitate development of commercial versions of the devices which show the most promise.