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Research Publications (Food Safety)

This page tracks research articles published in national and international peer-reviewed journals. Recent articles are available ahead of print and searchable by Journal, Article Title, and Category. Research publications are tracked across six categories: Bacterial Pathogens, Chemical Contaminants, Natural Toxins, Parasites, Produce Safety, and Viruses. Articles produced by USDA Grant Funding Agencies (requires login) and FDA Grant Funding Agencies (requires login) are also tracked in Scopus.

Displaying 226 - 250 of 709

  1. Orally Administered Human Immunoglobulin Therapy for Norovirus Enteritis in Solid Organ Transplant Recipients: A Case Series at a Single Academic Transplant Center

    • Clinical Infectious Diseases
    • Norovirus enteritis can cause intractable diarrhea in solid organ transplant (SOT) recipients, for which there are no established treatments. We reviewed medical records of 9 SOT recipients at our center who received orally administered human immunoglobulin for norovirus enteritis, and it appeared to be an effective treatment modality.

      • Norovirus
      • Viruses
  2. Detection, risk factors and molecular diversity of norovirus GIII in cattle in Uruguay

    • Infection, Genetics and Evolution
    • Author(s): Matías Castells, Rubén Darío Caffarena, María Laura Casaux, Carlos Schild, Felipe Castells, Daniel Castells, Matías Victoria, Franklin Riet-Correa, Federico Giannitti, Viviana Parreño, Rodney Colina

      • Viruses
      • Norovirus
  3. Identifying septic pollution exposure routes during a waterborne norovirus outbreak - A new application for human-associated microbial source tracking qPCR

    • Journal of Microbiological Methods
    • Author(s): Mia C. Mattioli, Katharine M. Benedict, Jennifer Murphy, Amy Kahler, Kelly E. Kline, Allison Longenberger, Patrick K. Mitchell, Sharon Watkins, Philip Berger, Orin C. Shanks, Catherine E. Barrett, Leslie Barclay, Aron J. Hall, Vincent Hill, Andre Weltman

      • Viruses
      • Norovirus
  4. Effect of Plant-derived Proteases on Infectivity of Tulane Virus, Murine Norovirus, and Hepatitis A Virus

    • Journal of Food Protection
    • Plant-derived proteases, bromelain, papain, and ficin are broad-acting enzymes with generally recognized as safe (GRAS) status for foods and have current application in several food industries. These proteases have also been reported to have antimicrobial properties.

      • Viruses
      • Norovirus
      • Hepatitis
  5. Detection of norovirus, hepatitis a and hepatitis E viruses in multicomponent foodstuffs

    • International Journal of Food Microbiology
    • Author(s): Catherine Hennechart-Collette, Océane Dehan, Michel Laurentie, Audrey Fraisse, Sandra Martin-Latil, Sylvie Perelle

      • Hepatitis
      • Norovirus
      • Viruses
  6. Characteristics of Norovirus Food Poisoning Outbreaks in Korea in the 2000s

    • Journal of Food Protection
    • Norovirus food poisoning outbreaks in Korea (South) appeared in 2000s and have been increasing since then. We aimed to investigate the epidemiological features of norovirus food poisoning outbreaks in Korea over the past years (2002 ~ 2017), based on official food poisoning statistics and available reports, and to find their association with climate factors. Norovirus was the most common cause of food poisoning among known causative substances in Korea during the study period.

      • Norovirus
      • Viruses
  7. Impact of a Multiplexed Polymerase Chain Reaction Panel on Identifying Diarrheal Pathogens in Hematopoietic Cell Transplant Recipients

    • Clinical Infectious Diseases
    • Background Diarrhea is common and associated with substantial morbidity among hematopoietic cell transplant (HCT) recipients, but the etiology is often not identified. Multiplexed polymerase chain reaction (PCR) assays increase the detection of diarrheal pathogens, but the impact of this technology in this population has not been evaluated.

      • Bacterial pathogens
      • Viruses
      • Norovirus
      • Yersinia
  8. Evaluation of viral co-infections among patients with community-associated Clostridioides difficile infection

    • PLOS ONE
    • by Lauren Korhonen, Jessica Cohen, Nicole Gregoricus, Monica M. Farley, Rebecca Perlmutter, Stacy M. Holzbauer, Ghinwa Dumyati, Zintars Beldavs, Ashley Paulick, Jan Vinjé, Brandi M. Limbago, Fernanda C. Lessa, Alice Y. Guh

      • Viruses
      • Norovirus
  9. Antiviral Effects of Lindera obtusiloba Leaf Extract on Murine Norovirus-1 (MNV-1), a Human Norovirus Surrogate, and Potential Application to Model Foods

    • Antibiotics
    • Noroviruses are the leading cause of acute gastroenteritis and food poisoning worldwide. In this study, we investigated the anti-noroviral activity of Lindera obtusiloba leaf extract (LOLE) using murine norovirus (MNV-1), a surrogate of human norovirus. Preincubation of MNV-1 with LOLE at 4, 8, or 12 mg/mL for 1 h at 25 °C significantly reduced viral infectivity, by 51.8%, 64.1%, and 71.2%, respectively.

      • Norovirus
      • Viruses
  10. Surveillance of human norovirus in oysters collected from production area in Shandong Province, China during 2017–2018

    • Food Control
    • Author(s): Hua'ning Zhang, Danlei Liu, Zilei Zhang, Joanne Hewitt, Xinpeng Li, Peibin Hou, Dapeng Wang, Qingping Wu

      • Norovirus
      • Viruses
  11. Efficacy of novel aqueous photo‐chlorine dioxide against a human norovirus surrogate, bacteriophage MS2, and Clostridium difficile endospores, in suspension, on stainless steel, and under greenhouse conditions

    • Journal of Applied Microbiology
    • ABSTRACT Aims The efficacy of a novel photochemical method for generating chlorine dioxide (photoClO2) was evaluated against human noroviruses (HuNoV) surrogate, bacteriophage MS2, and Clostridium difficile endospores. Methods and Results Chlorine dioxide was generated by mixing 1% sodium chlorite with 10 parts‐per‐million (ppm) Eosin Y and irradiating with a photo‐activator‐excitable light. PhotoClO2 efficacy was assessed against bacteriophage MS2 and C.

      • Norovirus
      • Viruses
      • Bacterial pathogens
  12. Molecular Characterization of Norovirus Circulating in Northwest Mexico During 2013–2014

    • Food and Environmental Virology
    • Norovirus (NoV) is an important etiological agent of diarrhea in children and adults. In Mexico, NoV screening is not routinely performed. NoV is highly infectious and is responsible for massive outbreaks due to the consumption of contaminated food. The study was a cross-sectional design. Samples of diarrheal stools were collected from (62) children and (38) adults with acute gastroenteritis during 2013–2014.

      • Norovirus
      • Viruses
  13. One-step duplex RT-droplet digital PCR assay for the detection of norovirus GI and GII in lettuce and strawberry

    • Food Microbiology
    • Author(s): Chongzhen Sun, Jiayin Chen, Hui Li, Ling Fang, Shiwei Wu, Pallavi Jayavanth, Shuze Tang, Gloria Sanchez, Xiyang Wu

      • Norovirus
      • Viruses
  14. Genomic Modeling as an Approach to Identify Surrogates for Use in Experimental Validation of SARS-CoV-2 and HuNoV Inactivation by UV-C Treatment

    • Frontiers in Microbiology
    • Severe Acute Respiratory Syndrome coronavirus-2 (SARS-CoV-2) is responsible for the COVID-19 pandemic that continues to pose significant public health concerns. While research to deliver vaccines and antivirals are being pursued, various effective technologies to control its environmental spread are also being targeted. Ultraviolet light (UV-C) technologies are effective against a broad spectrum of microorganisms when used even on large surface areas.

      • Norovirus
      • Hepatitis
      • Viruses
  15. Epidemiology and Genetic Characterization of Classical Human Astrovirus Infection in Shanghai, 2015–2016

    • Frontiers in Microbiology
    • Objective

      • Viruses
      • Norovirus
  16. Efficacy of alcohol‐based hand sanitizers against human norovirus using RNase‐RT‐qPCR with validation by human intestinal enteroid replication

    • Letters in Applied Microbiology
    • Successful human norovirus (HuNoV) cultivation in stem cell‐derived human intestinal enteroids (HIE) was recently reported. The purpose of this study was to evaluate the anti‐HuNoV efficacy of two alcohol‐based commercial hand sanitizers and 60% ethanol by suspension assay using RNase‐RT‐qPCR, with subsequent validation of efficacy by HuNoV cultivation using the HIE model.

      • Viruses
      • Norovirus
  17. Virucidal activity of three ethanol-based handrubs against murine norovirus in a hand hygiene clinical simulation study

    • Future Microbiology
    • Aim: We evaluated the efficacy of three ethanol-based hand rubs against murine norovirus in a proposed clinical simulation test (prEN 17430). Materials & methods: Virucidal activity was determined in 18 volunteers using three hand rubs: ethanol 72.4 and 89.5% v/v solutions, and 86% v/v gel. Subjects underwent testing with each product (3/6 ml for 15/30 s) and a reference solution (6 ml 70% v/v ethanol for 60 s).

      • Norovirus
      • Viruses
  18. Human norovirus exhibits strain-specific sensitivity to host interferon pathways in human intestinal enteroids

    • Proceedings of the National Academy of Sciences
    • Human noroviruses (HuNoVs) are the leading cause of viral gastroenteritis worldwide; yet currently, no vaccines or FDA-approved antiviral drugs are available to counter these pathogens. To understand HuNoV biology and the epithelial response to infection, we performed transcriptomic analyses, RT-qPCR, CRISPR-Cas9 modification of human intestinal enteroid (HIE) cultures, and functional...

      • Norovirus
      • Viruses
  19. Evaluating appropriateness and diagnostic stewardship opportunities of multiplex polymerase chain reaction gastrointestinal testing within a hospital system

    • Therapeutic Advances in Infectious Disease
    • Objective:This single-center, retrospective, observational cohort study evaluates the appropriateness of the BioFire® FilmArray® Gastrointestinal (GI) multiplex PCR panel testing at a community-teaching hospital.Methods:All adult, hospitalized patients at Prisma Health Richland Hospital with a documented GI multiplex PCR panel from 1 April 2015 through 28 February 2018 were included in the analysis.

      • Norovirus
      • Viruses
      • Bacterial pathogens
  20. The Basis of Peracetic Acid Inactivation Mechanisms for Rotavirus and Tulane Virus under Conditions Relevant for Vegetable Sanitation

    • Applied and Environmental Microbiology
    • We determined the disinfection efficacy and inactivation mechanisms of peracetic acid (PAA)-based sanitizer using pH values relevant for vegetable sanitation against rotavirus (RV) and Tulane virus (TV; a human norovirus surrogate). TV was significantly more resistant to PAA disinfection than RV: for a 2-log10 reduction of virus titer, RV required 1 mg/liter PAA for 3.5 min of exposure, while TV required 10 mg/liter PAA for 30 min.

      • Viruses
      • Norovirus
  21. Phylogenetic and biological characterizations of a GI.3 norovirus

    • Infection, Genetics and Evolution
    • Author(s): Lijun Zheng, Hanming Zhang, Jie Ma, Jinjin Liu, Shuhuan Ma, Mingchen Wang, Yuqi Huo

      • Viruses
      • Norovirus
  22. Thermal Inactivation of Hepatitis A Virus, Noroviruses, and Simian Rotavirus in Cows' Milk

    • Food and Environmental Virology
    • Consumption of raw or unpasteurized milk is a risk for the consumers because indirect contaminations such as fecal-cross-contamination could occur and determine the presence of enteric viruses.

      • Norovirus
      • Hepatitis
      • Viruses
  23. Application of an Optimized Direct Lysis Method for Viral RNA Extraction Linking Contaminated Dates to Infection With Hepatitis A Virus

    • Frontiers in Microbiology
    • Consumption of dates has not been considered a common risk of hepatitis A virus (HAV) infection. In January 2018, an outbreak of hepatitis was identified with cases resident in all regions of Denmark. All the detected strains belonged to HAV genotype 3A. Epidemiological investigations through patients’ interviews, case-control and trace-back studies pointed toward different batches of dates from a single producer as the vehicle of infection.

      • Norovirus
      • Hepatitis
      • Viruses
  24. Inactivation of hepatitis A virus and murine norovirus on surfaces of plastic, steel and raspberries using steam-ultrasound treatment

    • Food and Environmental Virology
    • The leading causes of foodborne viral disease outbreaks are human norovirus and hepatitis A virus (HAV). Their environmental persistence enables contamination of kitchen surfaces and crops often consumed raw, such as berries. Many decontamination procedures are inefficient and unsuitable for surfaces of industrial kitchen environments and soft fruits.

      • Norovirus
      • Hepatitis
      • Viruses
  25. Risk factors for sporadic norovirus infection: a systematic review and meta-analysis

    • Microbial Risk Analysis
    • Author(s): Anne Thébault, Julie David, Pauline Kooh, Vasco Cadavez, Ursula Gonzales-Barron, Nicole Pavio

      • Norovirus
      • Viruses