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Aggregate and Cumulative Risk of Pesticides: An On-Line Integrated Strategy (ACROPOLIS)


The project objectives will be addressed in five specific work packages as follows:
<UL><li>Improved cumulative exposure assessment and cumulative hazard assessment methodology;</li>
<li>New models for aggregated exposure assessment addressing different routes of exposure;</li>
<li>Setting up new toxicological testing for identifying possible synergistic effects and developing a strategy for refinement of cumulative assessment groups;</li>
<li>To integrate cumulative and aggregate risk models integrated in a web-based tool, including accessible data for all stakeholders;</li>
<li>Improving the understanding of cumulative risk assessment methodology of different stakeholders.</li></UL>

<P>This EU-funded project involves a consortium of eleven participants including Food and Environment Research Agency (FERA). The Food Standards Agency is part funding FERA's contribution to the project. Further information on ACROPOLIS (including details of the eleven participants) is available on its website - which will be updated as appropriate. The project aims to organize stakeholder conferences etc. as the project progresses. </P>

More information

<P>EU Directive 396/2005 states that methods are needed to account for cumulative and aggregate exposure in pesticides regulation. 27% of food samples had multiple residues in the 2006 EU residue monitoring report. The central aim of the ACROPLIS project is: to develop a framework for cumulative and aggregate risk assessment of pesticides in an understandable way, accessible for all those involved in European risk assessment and management. The project brings together the key experts and models in Europe including dietary exposure MCRA, dermal and inhalation exposure ConsExpo, user exposure EUROPOEM and UK POEM, dose-response PROAST and risk characterisation IPRA. The new integrated model will be tested in case studies with conazoles and pyrethroids and validated with biomarker and duplicate diet studies. The model software will be tested in different countries to ensure its usability at the international level. Overall ACROPOLIS will advance the scientific foundation to meet policy needs and protect EU consumers.</P>

<P>The objectives are published at: </P>

FERA - Food and Environment Research Agency
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