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Quantitative Procedures for Neurotoxicity Risk Assessment


To determine the necessary parameters for a biologically based dose-response model to predict neurotoxic adverse effects following exposure to cholinesterase-inhibiting pesticides. Such information would improve the ability of risk assessments to evaluate toxicological data for potential human health risk and address a specific need identified by the Neurotoxicity Risk Assessment Guidelines.

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FY 2000 Accomplishments: This EPA/NCTR IAG was established, postdoctoral support recruited and hired, and essential equipment purchased.

FY 2001 Plans:Develop a preliminary biologically based dose-response model for foodborne pesticides.

Slikker, Jr, William
DHHS/FDA - National Center for Toxicological Research
Project number