An official website of the United States government.

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

Regulation of a virulence switch in Acinetobacter baumannii


The Gram-negative bacterium Acinetobacter baumannii is a leading cause ofnosocomial infections in humans. The emergence of A. baumannii strains resistant tomost, and in some cases, all available antibiotics has made the treatment of theseinfections exceedingly difficult. This underlies the importance of finding new ways tocombat these infections. This proposal addresses regulation of a high-frequencyphenotypic switch in A. baumannii that controls virulence. The goals of this proposal areto understand regulatory mechanism responsible for this switch andidentify/characterize a quorum sensing signal that stimulates this switch.

Rather, Philip N.
Emory University
Start date
End date
Project number
Accession number