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Sample Search: Delivery of Test Articles to Mouse Lungs

Are there alternatives to the painful or distressful procedures being employed in the research on the delivery of test articles to mouse lungs?


Set Terms Items
1 intranasal* 28340
2 mouse OR mice 1877233
3 #1 AND #2 9800
4 method* OR technique* OR assay* OR test OR tests OR proceed* 1484
5 #1 NEAR/3 #4 583
6 #5 AND #2 158
7 "gene therapy*" OR ((gene or genetic) NEAR/3 vector*) 121195
8 ((#1 OR pulmonary OR intrapulmonary OR lung OR lungs) NEAR/4 (administ* OR instill*)) 47133
9 #7 AND #8 710
10 #8 NEAR/3 #4 1433
11 #10 AND #7 27
12 (blood near/5 (sampl* or collect*)) or bleed* 570103
13 repeat* near/4 ((blood near/5 (sampl* or collect*)) or bleed*) 3118
14 #13 AND #2 342
15 retroorbit* or "retro orbit*" or orbital* 172840
16 (#12 NEAR/4 #15) AND #2 251
17 isoflurane 32487
18 #8 AND #17 358

 


Databases Searched: Agricola, Medline, Biosis, CAB Abstracts


 Example Citations:

Set 6
A non-invasive intranasal inoculation technique using isoflurane anesthesia to infect the brain of mice with rabies virus.
Rosseels, V.; Nazé, F.; De Craeye, S.; Francart, A.; Kalai, M.; Van Gucht, S.
Journal of Virological Methods, 2011, 173 (1), 127-36. DOI: 10.1016/j.jviromet.2011.01.019

Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: effect of instillation volume and form of anesthesia.
Miller, M.A.; Stabenow, J.M.; Parvathareddy, J.; Wodowski, A.J.; Fabrizio, T.P.; Bina, X.R.; Zalduondo, L.; Bina, J.E.
PLoS ONE, 2012, 7 (2), Article No.: e31359. DOI: 10.1371/journal.pone.0031359

Distribution of intranasal instillations in mice: Effects of volume, time, body position, and anesthesia
Southam, D.S.; Dolovich, M.; O'Byrne, P.M.; Inman, M.D.
American Journal of Physiology, 2002, 282 (4 Part 1), L833-L839. DOI: 10.1152/ajplung.00173.2001
 

Set 11
Calculating expected lung deposition of aerosolized administration of AAV vector in human clinical studies.
Leung, K.; Louca, E.; Munson, K.; Dutzar, B.; Anklesaria, P.; Coates, A.L.
Journal of Gene Medicine, 2007, 9 (1), 10-21. DOI: 10.1002/jgm.987

LPS-induced bronchial hyperreactivity: interference by mIL-10 differs according to site of delivery.
Deleuze, V.; Lefort, J.; Bureau, M.F.; Scherman, D.; Vargaftig, B.B.
American journal of physiology, 2004, 286 (1 Part 1), L98-L105
 

Set 14
A modified serial blood sampling technique and utility of dried-blood spot technique in estimation of blood concentration: Application in mouse pharmacokinetics.
Kurawattimath, V.; Pocha, K.; Thanga Mariappan, T.; Trivedi, R.K.; Mandlekar, S.
European journal of drug metabolism and pharmacokinetics, 2012, 37 (1), 23-30. DOI: 10.1007/s13318-011-0066-5

Quality of plasma sampled by different methods for multiple blood sampling in mice.
Christensen, S.D.; Hansen, A.K.; Mikkelsen, L.F.; Fels, J.J.; Bodvarsdóttir, T.B.
Laboratory Animals, 2009, 43 (1), 65-71.

A good practice guide to the administration of substances and removal of blood, including routes and volumes.
Diehl, K.; Hull, R.; Morton, D.; Pfister, R.; Rabemampianina, Y.; Smith, D.; Vidal, J.; van de Vorstenbosch, C.
Journal of Applied Toxicology, 2001, 21 (1), 15-23. PDF

Cortisol and prolactin concentrations during repeated blood sample collection from freely moving, mouse-sized mammals (Phodopus spp.).
Reburn, C.J.; Wynne-Edwards, K.E.
Comparative medicine, 2000, 50 (2), 184-198.

 

Set 16
Alternatives to retroorbital blood collection in hispid cotton rats (Sigmodon hispidus).
Ayers, J.D.; Rota, P.A.; Collins, M.L.; Drew, C.P.
Journal of the American Association for Laboratory Animal Science, 2012, 51 (2), 239-245. PMC3314528

Clinical biochemistry parameters in C57BL/6J mice after blood collection from the submandibular vein and retroorbital plexus.
Silverman, J.
Journal of the American Association for Laboratory Animal Science, 2010, 49 (4), 400. PMC2846009

Pharmacokinetic comparisons of tail-bleeding with cannula- or retro-orbital bleeding techniques in rats using six marketed drugs.
Hui, Y.-h.; Huang, N.H.; Patel, N.; Ebbert, L.; Bina, H.; Maples, C.; Pritt, M.; Kern, T.; Chiang, A.
Journal of Pharmacological and Toxicological Methods, 2007, 56 (2), 256-264. DOI: 10.1016/j.vascn.2007.05.006

 

Set 18
Visualization of murine intranasal dosing efficiency using luminescent Francisella tularensis: Effect of instillation volume and form of anesthesia.
Miller, M.A.; Stabenow, J.M.; Parvathareddy, J.; Wodowski, A.J.; Fabrizio, T.P.; Bina, X.R.; Zalduondo, L.; Bina, J.E.; Fabrizio, T.P.
Plos one, 2012, 7 (2). DOI: 10.1371/journal.pone.0031359

Murine pulmonary inflammation model: A comparative study of anesthesia and instillation methods.
Lacher, S.E.; Johnson, C.; Jessop, F.; Holian, A.; Migliaccio, C.T.
Inhalation toxicology, 2010, 22 (1), 77-83. DOI: 10.3109/08958370902929969

An automatic video instillator for intratracheal instillation in the rat.
Kim, J.-S.; Lee, B.; Hwang, I.-C.; Yang, Y.-S.; Yang, M.-J.; Song, C.-W.; Kim, J.-S.
Laboratory Animals, 2010, 44 (1), 20-24. DOI: 10.1258/la.2009.009003

Distribution of intranasal instillations in mice: Effects of volume, time, body position, and anesthesia.
Southam, D.S.; Dolovich, M.; O'Byrne, P.M.; Inman, M.D.
American Journal of Physiology - Lung Cellular and Molecular Physiology, 2002, 282 (4 26-4).