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<ol> <LI> Consumption of food-borne bioactive compounds can protect against human diseases such as cancer, inflammation, birth defects, and microbial infection. We will determine the mechanisms by which selected compounds exert their protective action. <LI>Food-borne toxins and carcinogens are present per se or are induced by processing, preparation, and other post-harvest steps. We will identify mechanisms of action and develop biomarkers of natural and induced toxicants in food for human risk assessment and disease prevention. <LI>Selected classes of bioactive compounds show potential for beneficial or adverse effects on human health. We will discover bioactive compounds that have beneficial or adverse effects on human health.
NON-TECHNICAL SUMMARY: Obesity-associated metabolic disorders are escalating world-wide. Changes in life style, such as dietary recommendations form the cornerstone of treatment. The essential challenge for nutritional science is to identify not only nutritious foods, but (functional foods÷, that may provide health benefits beyond basic nutrition. The rationale for the proposed research is that understanding molecular events of functional foods has strong potential to identify effective nutritional intervention strategies and update dietary recommendation for a healthier living. <P>APPROACH: Investigate the ani-obesity, anti-diabetic and hypolipidemic properties of momordica charantia (bitter melon), using cell culture and animal model systems.